High-dose doxorubicin: an exploration of the dose-response curve in human neoplasia.

@article{Wheeler1982HighdoseDA,
  title={High-dose doxorubicin: an exploration of the dose-response curve in human neoplasia.},
  author={Richard H. Wheeler and William D. Ensminger and James Thrall and Jane L. Anderson},
  journal={Cancer treatment reports},
  year={1982},
  volume={66 3},
  pages={493-8}
}
Twenty-seven patients with advanced solid tumors (ten with lung cancer, eight with sarcoma, five with melanoma, four with miscellaneous tumors) were treated with high-dose doxorubicin (120 mg/m2) every 3 weeks for a total of 75 courses. As expected, marked myelosuppression was observed, with all patients having a granulocyte count nadir of less than 500 cells/mm3. The median platelet count nadir was 91 X 10(3)/mm3 following the first cycle and 50 X 10(3)/mm3 following the fourth cycle. Moderate… CONTINUE READING

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