High-dose daily opioid administration and poor functional status intensify local anesthetic injection pain in cancer patients.


BACKGROUND Evidence for opioid-induced hyperalgesia (OIH) has been shown in animal and human studies, but the clinical implications of this phenomenon remain unclear. OBJECTIVES We examined whether cancer patients taking opioids differ in their sensitivity to a clinical pain stimulus using a local anesthetic injection compared to those not taking opioids… (More)


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