High-dose cysteine administration does not increase synthesis of the antioxidant glutathione preterm infants.

@article{Braake2009HighdoseCA,
  title={High-dose cysteine administration does not increase synthesis of the antioxidant glutathione preterm infants.},
  author={Frans W J te Braake and Henk Schierbeek and Andr{\'a}s Vermes and Jan G. M. Huijmans and Johannes B van Goudoever},
  journal={Pediatrics},
  year={2009},
  volume={124 5},
  pages={e978-84}
}
OBJECTIVE Our aim was to evaluate whether administration of additional cysteine is safe and stimulates glutathione synthesis in preterm infants in early life. METHODS We conducted a prospective, randomized, clinical trial with infants with birth weights of <1500 g (N = 20). The infants were assigned randomly to receive either a standard dose (45 mg/kg per day) or a high dose (81 mg/kg per day) of cysteine. Intakes of other amino acids were similar, providing a total protein intake of 2.4 g/kg… CONTINUE READING