High-dose cyclophosphamide for poor-prognosis and recurrent pediatric brain tumors: a dose-escalation study.

Abstract

PURPOSE To determine the maximum-tolerated dose (MTD) of cyclophosphamide (CTX) when administered over 2 consecutive days followed by hematopoetic stem-cell rescue given as two sequential courses to children with glioblastoma multiforme, poor-prognosis pontine gliomas, and other recurrent CNS tumors. PATIENTS AND METHODS Two identical doses of CTX were… (More)

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@article{Yule1997HighdoseCF, title={High-dose cyclophosphamide for poor-prognosis and recurrent pediatric brain tumors: a dose-escalation study.}, author={Steven M. Yule and Nathan Foreman and Claire Mitchell and N Gouldon and P. May and Heather Prudence McDowell}, journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology}, year={1997}, volume={15 10}, pages={3258-65} }