High-dose cisplatin treatment: hearing loss and plasma concentrations.

  title={High-dose cisplatin treatment: hearing loss and plasma concentrations.},
  author={G{\"o}ran Laurell and U Jungnelius},
  journal={The Laryngoscope},
  volume={100 7},
Fifty-four patients with metastatic cancer were followed audiometrically during high-dose (100-120 mg/m2) cisplatin chemotherapy. Eighty-one percent of the patients showed significant changes in air-conduction hearing thresholds after completion of therapy. Thirteen percent sustained a significant hearing handicap. An interindividual variation was found, ranging from severe hearing loss after the first course to unaffected hearing after three courses. The ototoxic effect was not increased by… CONTINUE READING