High-dose circumferential chemodenervation of the internal anal sphincter: A new treatment modality for uncomplicated chronic anal fissure: A retrospective cohort study (with video).

@article{Glover2015HighdoseCC,
  title={High-dose circumferential chemodenervation of the internal anal sphincter: A new treatment modality for uncomplicated chronic anal fissure: A retrospective cohort study (with video).},
  author={Porter H. Glover and Shou-Jiang Tang and James Z Whatley and Eric D Davis and Kellen T Jex and Ruonan Wu and Christopher Lahr},
  journal={International journal of surgery},
  year={2015},
  volume={23 Pt A},
  pages={1-4}
}
BACKGROUND Botulinum toxin injection into the internal anal sphincter is gaining popularity as a second line therapy for chronic anal fissures if medical therapy fails. The dosage of botulinum toxin reported ranged from 20 to 50 IU with no more than 3 injection sites and results in a healing rate of 41%-88% at 3 months. We propose a new injection method of high-dose circumferential chemodenervation of 100 IU in treating chronic anal fissure. METHODS This was a retrospective review at a single… CONTINUE READING
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