High-dose chemotherapy with thiotepa, busulfan, and cyclophosphamide and autologous stem cell transplantation for pediatric primary central nervous system lymphoma in first complete remission.

@article{Rajagopal2017HighdoseCW,
  title={High-dose chemotherapy with thiotepa, busulfan, and cyclophosphamide and autologous stem cell transplantation for pediatric primary central nervous system lymphoma in first complete remission.},
  author={Revathi Rajagopal and Gordon C P Miles and Rishi S Kotecha},
  journal={Cancer},
  year={2017},
  volume={123 14},
  pages={2781-2782}
}
Primary central nervous system lymphoma (PCNSL) is rare in adults, and no standardized treatment options have been defined. Systemic chemotherapy with a high-dose methotrexate backbone is the mainstay of induction. Approaches to consolidation have consisted of wholebrain radiotherapy or high-dose chemotherapy with autologous stem cell transplantation (HDC-ASCT). PCNSL is exceedingly rare in children, with approximately 100 cases described over the last 20 years. As with adults, diffuse large B… CONTINUE READING