High-dose chemotherapy in breast cancer.

@article{Lake2004HighdoseCI,
  title={High-dose chemotherapy in breast cancer.},
  author={Diana E. Lake and Clifford A. Hudis},
  journal={Drugs},
  year={2004},
  volume={64 17},
  pages={
          1851-60
        }
}
High-dose chemotherapy is based on the scientific hypothesis that escalating the dose of drug will overcome drug resistance and improve outcome. Autologous bone marrow transplantation and, more recently, peripheral stem cell transplantation used as a means to restore marrow, made this a viable treatment for patients with selected tumours such as haematological malignancies. The role in breast cancer is less certain. Given the known as well as the potential toxicities, the objective of high-dose… CONTINUE READING

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