High-dose chemotherapy followed by autologous stem cell transplantation as first-line therapy in aggressive non-Hodgkin's lymphoma: a meta-analysis.

@article{Strehl2003HighdoseCF,
  title={High-dose chemotherapy followed by autologous stem cell transplantation as first-line therapy in aggressive non-Hodgkin's lymphoma: a meta-analysis.},
  author={John W. Strehl and Ulrich J. M. Mey and Axel Glasmacher and Benjamin Djulbegovic and Christine Mayr and Marcus Gorschlueter and Carsten G Ziske and Ingo G. H. Schmidt-Wolf},
  journal={Haematologica},
  year={2003},
  volume={88 11},
  pages={1304-15}
}
BACKGROUND AND OBJECTIVES High-dose chemotherapy followed by autologous stem cell transplantation (HDT/ASCT) has proven to be superior to conventional chemotherapy in patients with chemosensitive relapse of aggressive non-Hodgkin's lymphoma (NHL). Therefore, HDT/ASCT was evaluated as part of first-line therapy. Several trials generated conflicting results. This meta-analysis summarizes the available evidence from all suitable studies. DESIGN AND METHODS Prospective, randomized trials with HDT… CONTINUE READING