High dose chemotherapy and autologous hematopoietic stem cell transplantation for rheumatoid arthritis: a review.

@article{Verburg2002HighDC,
  title={High dose chemotherapy and autologous hematopoietic stem cell transplantation for rheumatoid arthritis: a review.},
  author={R obert J Verburg and Ren{\'e} E M Toes and Willem E. Fibbe and Ferdinand C. Breedveld and Jacob M van Laar},
  journal={Human immunology},
  year={2002},
  volume={63 8},
  pages={627-37}
}
A new treatment approach, involving intense immunosuppression and autologous hematopoietic stem cell transplantation (SCT), has emerged in recent years for the treatment of severe, refractory rheumatic autoimmune diseases including rheumatoid arthritis (RA). The rationale of this strategy is based on the concept of immunoablation by intense immunosuppression with subsequent regeneration of naïve T lymphocytes derived from reinfused hematopoietic progenitor cells. Patients with a therapy… CONTINUE READING