High-dose aspirin inhibits shear-induced platelet reaction involving thrombin generation.

@article{Ratnatunga1992HighdoseAI,
  title={High-dose aspirin inhibits shear-induced platelet reaction involving thrombin generation.},
  author={C P Ratnatunga and Steve Edmondson and Gareth M Rees and Iren B. Kov{\'a}cs},
  journal={Circulation},
  year={1992},
  volume={85 3},
  pages={1077-82}
}
BACKGROUND A unifying concept of explaining all pharmacological actions of aspirin by the irreversible blockage of the enzyme cyclooxygenase and therefore the inhibition of prostaglandin biosynthesis has left many unanswered questions. METHODS AND RESULTS Two hundred ninety-four patients taking 75 mg/day aspirin were tested 3 months after coronary artery bypass surgery. Platelet thromboxane formation (whole blood aggregation to arachidonate) was completely prevented in 80% of patients… CONTINUE READING
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Aspirin. Sci Am 1991;264:58-64

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