High-dose aprotinin reduces blood loss in patients undergoing total hip replacement surgery.

@article{Janssens1994HighdoseAR,
  title={High-dose aprotinin reduces blood loss in patients undergoing total hip replacement surgery.},
  author={Ml Janssens and J Joris and Jpr David and Rapha{\"e}l Lemaire and Maurice Lamy},
  journal={Anesthesiology},
  year={1994},
  volume={80 1},
  pages={
          23-9
        }
}
BACKGROUND Aprotinin, a proteinase inhibitor, has been reported to reduce blood loss significantly during cardiac surgery. The mechanisms of this effect remain unclear. We studied the effect of aprotinin on blood loss and transfusion requirement during total hip replacement. Potential mechanisms of action and side effects also were investigated. METHODS Forty patients scheduled for primary total hip replacement were randomized to receive, in double-blind fashion, either aprotinin given as a… CONTINUE READING

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