High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: efficacy and safety.

@article{Wiedermann2006HighdoseAI,
  title={High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: efficacy and safety.},
  author={Christian J Wiedermann and Johannes N. Hoffmann and Mathias Juers and Helmut Ostermann and Joachim Kienast and Josef Briegel and Richard Strauss and H. -O. Keinecke and Brian L Warren and Steven M. Opal},
  journal={Critical care medicine},
  year={2006},
  volume={34 2},
  pages={285-92}
}
OBJECTIVE To explore if patients with severe sepsis and with a predicted high risk of death (according to the Simplified Acute Physiology Score II) might have a treatment benefit from high-dose antithrombin III. DESIGN Subgroup analysis of a randomized, placebo-controlled, double-blind, prospective phase III study. SETTING Unifactorial and multifactorial reanalysis of prospectively defined populations from the KyberSept trial. PATIENTS We studied 1,008 patients (43.6% of the overall… CONTINUE READING

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