High-dose N-acetylcysteine in patients with exacerbations of chronic obstructive pulmonary disease.

@article{Zuin2005HighdoseNI,
  title={High-dose N-acetylcysteine in patients with exacerbations of chronic obstructive pulmonary disease.},
  author={Renzo Zuin and A Palamidese and R S Negrin and L Catozzo and Angelo Scarda and Matheus Balbinot},
  journal={Clinical drug investigation},
  year={2005},
  volume={25 6},
  pages={401-8}
}
OBJECTIVE To investigate the efficacy and tolerability of high-dose N-acetylcysteine (NAC) in the treatment of patients with exacerbations of chronic obstructive pulmonary disease (COPD). DESIGN AND PATIENTS Randomised, double-blind, double-dummy, placebo-controlled study in 123 patients experiencing an acute exacerbation of COPD. INTERVENTIONS NAC 1200 mg/day, 600 mg/day or placebo administered once daily for 10 days. MAIN OUTCOME MEASURES The primary objective was to assess the… CONTINUE READING