High-dose 5-Fluorouracil with uridine-diphosphoglucose rescue increases thymidylate synthase inhibition but not 5-Fluorouracil incorporation into RNA in murine tumors.

@article{CodacciPisanelli2002Highdose5W,
  title={High-dose 5-Fluorouracil with uridine-diphosphoglucose rescue increases thymidylate synthase inhibition but not 5-Fluorouracil incorporation into RNA in murine tumors.},
  author={Giovanni Codacci-Pisanelli and Clasina L van der Wilt and K. Smid and Paul Noordhuis and Daphne Voorn and Herbert M. Pinedo and Godefridus J. Peters},
  journal={Oncology},
  year={2002},
  volume={62 4},
  pages={363-70}
}
5-Fluorouracil (5FU) shows a steep dose response curve in several experimental systems, but the clinical use of high doses is hampered by the toxic side effects of this drug. Uridine diphosphoglucose (UDPG) rescue allows an increase in the maximum tolerated dose of 5FU in mice from 100 (FU(100)) to 150 mg/kg (5FU(150)+UDPG) and the higher dose is more effective than the standard treatment against several tumors. In the present paper we report on the effect of high-dose 5FU on thymidylate… CONTINUE READING