High-dose 1,2,4-triglycidylurazol given in regimens preparatory to bone marrow transplantation

Abstract

To elucidate its potential role in the framework of bone marrow transplantation, we studied the toxicologic and pharmacologic properties of high doses of the triepoxide derivate 1,2,4-triglycidylurazol (TGU) in a preclinical dog model. Dose-dependent and dose-limiting gastrointestinal toxicity occurred in a dose range between 40 and 75 mg/kg, with the… (More)
DOI: 10.1007/BF00688858

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