High-dimensional propensity score algorithm in comparative effectiveness research with time-varying interventions.
@article{Neugebauer2015HighdimensionalPS,
title={High-dimensional propensity score algorithm in comparative effectiveness research with time-varying interventions.},
author={Romain Neugebauer and Julie A. Schmittdiel and Zheng Zhu and Jeremy A. Rassen and John D. Seeger and Sebastian Schneeweiss},
journal={Statistics in medicine},
year={2015},
volume={34 5},
pages={
753-81
}
}The high-dimensional propensity score (hdPS) algorithm was proposed for automation of confounding adjustment in problems involving large healthcare databases. [] Key Method We describe the application and performance of the hdPS algorithm to improve covariate selection in CER with time-varying interventions based on IPW estimation and explore stabilization of the resulting estimates using Super Learning. The evaluation is based on both the analysis of electronic health records data in a real-world CER study…
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References
SHOWING 1-10 OF 87 REFERENCES
Targeted learning in real-world comparative effectiveness research with time-varying interventions.
- EconomicsStatistics in medicine
- 2014
This application establishes the feasibility of TMLE in real-world CER based on large healthcare databases and provides evidence of proper confounding and selection bias adjustment with TMLE and SL, and motivates their application for improving estimation efficiency.
High-dimensional Propensity Score Adjustment in Studies of Treatment Effects Using Health Care Claims Data
- MedicineEpidemiology
- 2009
In typical pharmacoepidemiologic studies, the proposed high-dimensional propensity score resulted in improved effect estimates compared with adjustment limited to predefined covariates, when benchmarked against results expected from randomized trials.
Covariate selection in high-dimensional propensity score analyses of treatment effects in small samples.
- PsychologyAmerican journal of epidemiology
- 2011
Hd-PS is a flexible analytical tool for nonrandomized research across a range of study sizes and event frequencies and allowed to function robustly with few events in 4 North American pharmacoepidemiologic cohort studies between 1995 and 2005.
Using high‐dimensional propensity scores to automate confounding control in a distributed medical product safety surveillance system
- Computer SciencePharmacoepidemiology and drug safety
- 2012
The use of hd‐PS for automating confounding control in sequential database cohort studies, as applied to safety monitoring systems is discussed and it is concluded that despite certain limitations, hd-PS offers substantial advantages over non‐automated alternatives in active productSafety monitoring systems.
Marginal structural models for analyzing causal effects of time-dependent treatments: an application in perinatal epidemiology.
- MedicineAmerican journal of epidemiology
- 2004
The objective of this paper is to illustrate the fitting of an MSM for the causal effect of iron supplement use during pregnancy (time-varying treatment) on odds of anemia at delivery in the presence of time-dependent confounding.
Super learning to hedge against incorrect inference from arbitrary parametric assumptions in marginal structural modeling.
- MedicineJournal of clinical epidemiology
- 2013
A Marginal Structural Modeling Approach with Super Learning for a Study on Oral Bisphosphonate Therapy and Atrial Fibrillation
- Medicine
- 2013
An effort to specifically address challenges with marginal structural modeling based on inverse probability weighting with data reduction and super learning is described.
A Marginal Structural Modeling Approach with Super Learning for a Study on Oral Bisphosphonate Therapy and Atrial Fibrillation
- Medicine
- 2013
An effort to specifically address challenges with marginal structural modeling based on inverse probability weighting with data reduction and super learning to provide a feasible alternative to extended Cox modeling or the point treatment analytic approaches that are often adopted in safety research with large data sets.
Comparison of dynamic treatment regimes via inverse probability weighting.
- MathematicsBasic & clinical pharmacology & toxicology
- 2006
A simple method to compare dynamic treatment regimes by artificially censoring subjects and then using inverse probability weighting (IPW) to adjust for any selection bias introduced by the artificial censoring is described.
Dynamic marginal structural modeling to evaluate the comparative effectiveness of more or less aggressive treatment intensification strategies in adults with type 2 diabetes
- Medicine, PsychologyPharmacoepidemiology and drug safety
- 2012
Under explicit assumptions, the application of inverse probability weighting estimation to fit dynamic marginal structural models (MSMs) in observational studies to address pragmatic CER questions and properly adjust for time‐dependent confounding and informative loss to follow-up is motivated.










