High-dimensional immune profiling of total and rotavirus VP6-specific intestinal and circulating B cells by mass cytometry

@inproceedings{Nair2016HighdimensionalIP,
  title={High-dimensional immune profiling of total and rotavirus VP6-specific intestinal and circulating B cells by mass cytometry},
  author={Nitya Nair and Vincenzo W Cerundolo and Christopher Vollmers and Stephen R Quake and John Maga{\~n}a Morton and Mark M. Davis and Xiaosong He and Harry B Greenberg},
  booktitle={Mucosal immunology},
  year={2016}
}
In-depth phenotyping of human intestinal antibody secreting cells (ASCs) and their precursors is important for developing improved mucosal vaccines. We used single-cell mass cytometry to simultaneously analyze 34 differentiation and trafficking markers on intestinal and circulating B cells. In addition, we labeled rotavirus (RV) double-layered particles with a metal isotope and characterized B cells specific to the RV VP6 major structural protein. We describe the heterogeneity of the intestinal… CONTINUE READING
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