High dimensional endophenotype ranking in the search for major depression risk genes.

@article{Glahn2012HighDE,
  title={High dimensional endophenotype ranking in the search for major depression risk genes.},
  author={David C. Glahn and Joanne E. Curran and Anderson M. Winkler and Melanie A. Carless and Jack W. Kent and Jac C Charlesworth and Matthew P. Johnson and Harald H. G{\"o}ring and S. A. Cole and Thomas D. Dyer and E. K. Moses and Rene L. Olvera and Peter V. Kochunov and Ravi K. Duggirala and Peter T. Fox and Laura Almasy and John Blangero},
  journal={Biological psychiatry},
  year={2012},
  volume={71 1},
  pages={6-14}
}
BACKGROUND Despite overwhelming evidence that major depression is highly heritable, recent studies have localized only a single depression-related locus reaching genome-wide significance and have yet to identify a causal gene. Focusing on family-based studies of quantitative intermediate phenotypes or endophenotypes, in tandem with studies of unrelated individuals using categorical diagnoses, should improve the likelihood of identifying major depression genes. However, there is currently no… CONTINUE READING
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