High dimensional endophenotype ranking in the search for major depression risk genes.

  title={High dimensional endophenotype ranking in the search for major depression risk genes.},
  author={David C. Glahn and Joanne E. Curran and Anderson M. Winkler and Melanie A. Carless and Jack W. Kent and Jac C Charlesworth and Matthew P. Johnson and Harald H. G{\"o}ring and S. A. Cole and Thomas D. Dyer and E. K. Moses and Rene L. Olvera and Peter V. Kochunov and Ravi K. Duggirala and Peter T. Fox and Laura Almasy and John Blangero},
  journal={Biological psychiatry},
  volume={71 1},
BACKGROUND Despite overwhelming evidence that major depression is highly heritable, recent studies have localized only a single depression-related locus reaching genome-wide significance and have yet to identify a causal gene. Focusing on family-based studies of quantitative intermediate phenotypes or endophenotypes, in tandem with studies of unrelated individuals using categorical diagnoses, should improve the likelihood of identifying major depression genes. However, there is currently no… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 9 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 78 extracted citations

Bringing genetics back to psychiatric endophenotypes.

Biological psychiatry • 2012
View 9 Excerpts
Highly Influenced

Lifetime major depression and grey-matter volume

Journal of psychiatry & neuroscience : JPN • 2018


Publications referenced by this paper.
Showing 1-10 of 67 references

The endophenotype concept in psychiatry: etymology and strategic intentions.

The American journal of psychiatry • 2003
View 4 Excerpts
Highly Influenced

Common genetic influences on depression, alcohol, and substance use disorders in Mexican-American families.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics • 2011
View 2 Excerpts

Similar Papers

Loading similar papers…