High dietary n-6/n-3 PUFA ratio promotes HDL cholesterol level, but does not suppress atherogenesis in apolipoprotein E-null mice 1.

@article{Zhang2009HighDN,
  title={High dietary n-6/n-3 PUFA ratio promotes HDL cholesterol level, but does not suppress atherogenesis in apolipoprotein E-null mice 1.},
  author={Liang Zhang and Yue Geng and Ning Xiao and Miao Yin and Liufeng Mao and Guocheng Ren and Peng Liu and Nannan Lu and Liguo An and Jie Pan},
  journal={Journal of atherosclerosis and thrombosis},
  year={2009},
  volume={16 4},
  pages={
          463-71
        }
}
AIM Dietary fatty acids affect atherogenesis, which was presumed to be partly related to HDL cholesterol (HDL-C) metabolism. The major aim of the work was to analyze various ratios of n-6/n-3 PUFA diets on HDL-C metabolism in apolipoprotein E-null (apoE(-/-)) mice, which have similar symptoms to human type III familial hyperlipoproteinemia. METHODS Two-month-old male apoE(-/-) mice were fed four types of n-6/n-3 PUFA diet (group 1, 1.28; group 2, 5.03; group 3, 9.98 and group 4, 68.26) and… CONTINUE READING

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