High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex

@article{Zhang2005HighDF,
  title={High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex},
  author={Xiaochun Zhang and Feng Dong and Jun Ren and Meghan J. Driscoll and Bruce W. Culver},
  journal={Experimental Neurology},
  year={2005},
  volume={191},
  pages={318-325}
}
Epidemiological and experimental studies have suggested that high dietary intake of fats is associated with cognitive decline and a significantly increased risk of dementia. Since oxidative stress and inflammation have been speculated to be critical mechanisms underlying neurodegenerative diseases, we hypothesized that a high fat (HF) diet might induce cerebral oxidative stress or neural inflammation and subsequently contribute to the high risk of dementia. To test this hypothesis, male rats… CONTINUE READING
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