High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-β and tau pathologies in the 3xTg-AD model of Alzheimer's disease

@article{Phivilay2009HighDC,
  title={High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-β and tau pathologies in the 3xTg-AD model of Alzheimer's disease},
  author={A. Phivilay and C. Julien and C. Tremblay and L. Berthiaume and F. Calon},
  journal={Neuroscience},
  year={2009},
  volume={159},
  pages={296-307}
}
  • A. Phivilay, C. Julien, +2 authors F. Calon
  • Published 2009
  • Chemistry, Medicine
  • Neuroscience
  • Dietary consumption of trans fatty acids (TFA) has increased during the 20th century and is a suspected risk factor for cardiovascular diseases. More recently, high TFA intake has been associated with a higher risk of developing Alzheimer's disease (AD). To investigate the impact of TFA on an animal model genetically programmed to express amyloid-beta (Abeta) and tau pathological markers of AD, we have fed 3xTg-AD mice with either control (0% TFA/total fatty acid), high TFA (16% TFA) or very… CONTINUE READING
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