High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-β and tau pathologies in the 3xTg-AD model of Alzheimer's disease

@article{Phivilay2009HighDC,
  title={High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-$\beta$ and tau pathologies in the 3xTg-AD model of Alzheimer's disease},
  author={Alix Phivilay and Carl Julien and Cynthia Tremblay and Line Berthiaume and Pierre Julien and Yves Gigu{\`e}re and Fr{\'e}d{\'e}ric Calon},
  journal={Neuroscience},
  year={2009},
  volume={159},
  pages={296-307}
}
Dietary consumption of trans fatty acids (TFA) has increased during the 20th century and is a suspected risk factor for cardiovascular diseases. More recently, high TFA intake has been associated with a higher risk of developing Alzheimer's disease (AD). To investigate the impact of TFA on an animal model genetically programmed to express amyloid-beta (Abeta) and tau pathological markers of AD, we have fed 3xTg-AD mice with either control (0% TFA/total fatty acid), high TFA (16% TFA) or very… Expand
PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis.
TLDR
Results suggest a protective role for PPARα in the pathological changes in the liver following TFA consumption, which might prevent TFA-containing diet-induced steatohepatitis. Expand
N-3 fatty acids reduced trans fatty acids retention and increased docosahexaenoic acid levels in the brain
TLDR
Dietary n-3 PUFA decreased TFA retention and increased DHA accretion in the brain and the results underscore the importance of the type of dietary FA on the retention of TFA in the head and also on the changes of the FA profile. Expand
Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP).
TLDR
This in vitro study systematically investigates whether the regulated intramembrane proteolysis of the amyloid precursor protein (APP) is affected by trans fatty acids compared to the cis conformation, and shows that oligomerization and aggregation of Aβ are increased byTrans fatty acids. Expand
Omega-3 polyunsaturated fatty acids and brain health: Preclinical evidence for the prevention of neurodegenerative diseases
TLDR
Evidence is provided that adjustments in the consumption of dietary lipids alone or combined with other nutrients may be a cost-effective intervention to optimize brain function and prevent AD or PD. Expand
High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology☆
TLDR
It is indicated that a high-fat diet has rapid and long-lasting negative effects on memory in both control and AD mice that are associated with neuroinflammation, but independent of changes in beta amyloid and tau neuropathology in the AD mice. Expand
Effects of a normolipidic diet containing trans fatty acids during perinatal period on the growth, hippocampus fatty acid profile, and memory of young rats according to sex.
TLDR
The TFAs were incorporated in small amounts in the hippocampus and did not affect aversive memory, however, spatial memory was modified in young rats fed with a diet rich in TFAs and the provision of essential fatty acids and the ω-6/ω-3 ratio suggested. Expand
Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-β peptide in high-fat and high-sucrose-fed rats
TLDR
Observation shows that EE may rescue diet-induced amyloid and tau pathology in high-fat and high-sucrose-fed rats. Expand
Reduced blood‐brain barrier expression of fatty acid‐binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega‐3 fatty acid diets
TLDR
This study demonstrates FABP5 deficiency and impaired DHA transport at the BBB are associated with increased vulnerability to cognitive deficits in mice fed an n‐3 fatty acid‐depleted diet, in line with previous studies demonstrating a crucial role of FABp5 in BBB transport of DHA and cognitive function. Expand
Trans-fatty acids alter the gut microbiota in high-fat-diet-induced obese rats
TLDR
It was found that the TFA/HF diets significantly induced obesity and changes in blood and brain physiological parameters of the rats, and significant differences were observed among clusters of orthologous group functional categories of the four dietary groups. Expand
Cross‐generational trans fat intake modifies BDNF mRNA in the hippocampus: Impact on memory loss in a mania animal model
TLDR
These findings confirm that provision of n‐3 or TFA during development over two generations is able to change the neuronal membrane lipid composition, protecting or impairing the hippocampus, respectively, thus affecting neurothrophic factor expression such as BDNF mRNA. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 74 REFERENCES
A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model
TLDR
DHA modulated APP processing by decreasing both α- and β-APP C-terminal fragment products and full-length APP, which suggests DHA could be protective against β-amyloid production, accumulation, and potential downstream toxicity. Expand
High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model
TLDR
Low n-3:n-6 PUFA intake ratio increased insoluble tau regardless of total fat consumption, whereas high-fat diet incorporating a low n- 3: n-n- 6 PUFA ratio also increased soluble tau compared to controls. Expand
Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-β and Tau Pathology via a Mechanism Involving Presenilin 1 Levels
TLDR
DHA and DPAn-6 supplementations could be a beneficial natural therapy for AD, with the novel finding that the mechanism accounting for the reduction in soluble Aβ was attributable to a decrease in steady-state levels of presenilin 1, and not to altered processing of the amyloid precursor protein by either the α- or β-secretase. Expand
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice
TLDR
DHA diet decreased the number of activated microglia in hippocampus and increased exploratory activity of transgenic mice, but did not improve their spatial learning in the water maze. Expand
Dietary Fat–Induced Alterations in Atherosclerosis Are Abolished by ACAT2-Deficiency in ApoB100 Only, LDLr−/− Mice
TLDR
The results indicate that in apoB100 only, LDLr−/− mice, ACAT2 plays an essential role in facilitating dietary fat type–specific atherosclerosis through its various effects on plasma lipoprotein concentration and composition. Expand
Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction.
TLDR
It is suggested that higher intake of trans fatty acids could adversely affect endothelial function, which might partially explain why the positive relation between trans fat and cardiovascular risk is greater than one would predict based solely on its adverse effects on lipids. Expand
Dietary n‐3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease
TLDR
The marked effect of dietary n‐3 PFA on NMDA receptors and caspase/calpain activation in the cortex of an animal model of AD provide new insights into how dietary essential fatty acids may influence cognition and AD risk. Expand
Intake of Sucrose-sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer Disease*
TLDR
It is concluded that the up-regulation of apoE accelerated the aggregation of Aβ, resulting in the exacerbation of cerebral amyloidosis in sucrose-treated mice, and suggesting that controlling the consumption of sugar-sweetened beverages may be an effective way to curtail the risk of developing AD. Expand
Dietary trans fatty acids: effects on plasma lipids and lipoproteins of healthy men and women.
TLDR
Compared with oleic acid, dietary TFAs raise LDL cholesterol, but to a slightly lesser degree than do saturates, and high TFA concentrations may result in minor reductions of HDL cholesterol. Expand
Dietary trans fatty acids combined with a marginal essential fatty acid status during the pre- and postnatal periods do not affect growth or brain fatty acids but may alter behavioral development in B6D2F(2) mice.
TLDR
Findings illustrate that TFA combined with a marginal EFA status do not exacerbate the effects of marginal E FA status on growth or brain LC-PUFA, however, long-term effects of dietary TFA during the pre- and postnatal period on behavioral development and neural function should be investigated in future studies. Expand
...
1
2
3
4
5
...