High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-β and tau pathologies in the 3xTg-AD model of Alzheimer's disease

  title={High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-$\beta$ and tau pathologies in the 3xTg-AD model of Alzheimer's disease},
  author={Alix Phivilay and Carl Julien and Cynthia Tremblay and Line Berthiaume and Pierre Julien and Yves Gigu{\`e}re and Fr{\'e}d{\'e}ric Calon},

PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis.

N-3 fatty acids reduced trans fatty acids retention and increased docosahexaenoic acid levels in the brain

Dietary n-3 PUFA decreased TFA retention and increased DHA accretion in the brain and the results underscore the importance of the type of dietary FA on the retention of TFA in the head and also on the changes of the FA profile.

Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-β peptide in high-fat and high-sucrose-fed rats

Observation shows that EE may rescue diet-induced amyloid and tau pathology in high-fat and high-sucrose-fed rats.

Reduced blood‐brain barrier expression of fatty acid‐binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega‐3 fatty acid diets

This study demonstrates FABP5 deficiency and impaired DHA transport at the BBB are associated with increased vulnerability to cognitive deficits in mice fed an n‐3 fatty acid‐depleted diet, in line with previous studies demonstrating a crucial role of FABp5 in BBB transport of DHA and cognitive function.

Trans-fatty acids alter the gut microbiota in high-fat-diet-induced obese rats

It was found that the TFA/HF diets significantly induced obesity and changes in blood and brain physiological parameters of the rats, and significant differences were observed among clusters of orthologous group functional categories of the four dietary groups.

Cross‐generational trans fat intake modifies BDNF mRNA in the hippocampus: Impact on memory loss in a mania animal model

These findings confirm that provision of n‐3 or TFA during development over two generations is able to change the neuronal membrane lipid composition, protecting or impairing the hippocampus, respectively, thus affecting neurothrophic factor expression such as BDNF mRNA.

Neurochemical Effects of Long Term Consumption of High Fat Diet

Early onset ofinflammation in the hypothalamus relative to that in peripheral tissues suggests that different processes may cause inflammation in the peripheral tissues and hypothalamus.



A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model

DHA modulated APP processing by decreasing both α- and β-APP C-terminal fragment products and full-length APP, which suggests DHA could be protective against β-amyloid production, accumulation, and potential downstream toxicity.

Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-β and Tau Pathology via a Mechanism Involving Presenilin 1 Levels

DHA and DPAn-6 supplementations could be a beneficial natural therapy for AD, with the novel finding that the mechanism accounting for the reduction in soluble Aβ was attributable to a decrease in steady-state levels of presenilin 1, and not to altered processing of the amyloid precursor protein by either the α- or β-secretase.

Dietary Fat–Induced Alterations in Atherosclerosis Are Abolished by ACAT2-Deficiency in ApoB100 Only, LDLr−/− Mice

The results indicate that in apoB100 only, LDLr−/− mice, ACAT2 plays an essential role in facilitating dietary fat type–specific atherosclerosis through its various effects on plasma lipoprotein concentration and composition.

Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction.

It is suggested that higher intake of trans fatty acids could adversely affect endothelial function, which might partially explain why the positive relation between trans fat and cardiovascular risk is greater than one would predict based solely on its adverse effects on lipids.

Dietary n‐3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease

The marked effect of dietary n‐3 PFA on NMDA receptors and caspase/calpain activation in the cortex of an animal model of AD provide new insights into how dietary essential fatty acids may influence cognition and AD risk.

Intake of Sucrose-sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer Disease*

It is concluded that the up-regulation of apoE accelerated the aggregation of Aβ, resulting in the exacerbation of cerebral amyloidosis in sucrose-treated mice, and suggesting that controlling the consumption of sugar-sweetened beverages may be an effective way to curtail the risk of developing AD.

Dietary trans fatty acids: effects on plasma lipids and lipoproteins of healthy men and women.

Compared with oleic acid, dietary TFAs raise LDL cholesterol, but to a slightly lesser degree than do saturates, and high TFA concentrations may result in minor reductions of HDL cholesterol.

Dietary trans fatty acids combined with a marginal essential fatty acid status during the pre- and postnatal periods do not affect growth or brain fatty acids but may alter behavioral development in B6D2F(2) mice.

Findings illustrate that TFA combined with a marginal EFA status do not exacerbate the effects of marginal E FA status on growth or brain LC-PUFA, however, long-term effects of dietary TFA during the pre- and postnatal period on behavioral development and neural function should be investigated in future studies.