High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-β and tau pathologies in the 3xTg-AD model of Alzheimer's disease

@article{Phivilay2009HighDC,
  title={High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-$\beta$ and tau pathologies in the 3xTg-AD model of Alzheimer's disease},
  author={Alix Phivilay and Carl Julien and Cynthia Tremblay and Line Berthiaume and Pierre Julien and Yves Gigu{\`e}re and Fr{\'e}d{\'e}ric Calon},
  journal={Neuroscience},
  year={2009},
  volume={159},
  pages={296-307}
}

PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis.

N-3 fatty acids reduced trans fatty acids retention and increased docosahexaenoic acid levels in the brain

Dietary n-3 PUFA decreased TFA retention and increased DHA accretion in the brain and the results underscore the importance of the type of dietary FA on the retention of TFA in the head and also on the changes of the FA profile.

Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-β peptide in high-fat and high-sucrose-fed rats

Observation shows that EE may rescue diet-induced amyloid and tau pathology in high-fat and high-sucrose-fed rats.

Reduced blood‐brain barrier expression of fatty acid‐binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega‐3 fatty acid diets

This study demonstrates FABP5 deficiency and impaired DHA transport at the BBB are associated with increased vulnerability to cognitive deficits in mice fed an n‐3 fatty acid‐depleted diet, in line with previous studies demonstrating a crucial role of FABp5 in BBB transport of DHA and cognitive function.

Trans-fatty acids alter the gut microbiota in high-fat-diet-induced obese rats

It was found that the TFA/HF diets significantly induced obesity and changes in blood and brain physiological parameters of the rats, and significant differences were observed among clusters of orthologous group functional categories of the four dietary groups.

Cross‐generational trans fat intake modifies BDNF mRNA in the hippocampus: Impact on memory loss in a mania animal model

These findings confirm that provision of n‐3 or TFA during development over two generations is able to change the neuronal membrane lipid composition, protecting or impairing the hippocampus, respectively, thus affecting neurothrophic factor expression such as BDNF mRNA.

Neurochemical Effects of Long Term Consumption of High Fat Diet

Early onset ofinflammation in the hypothalamus relative to that in peripheral tissues suggests that different processes may cause inflammation in the peripheral tissues and hypothalamus.
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