Corpus ID: 14775603

High-density marker analysis of 11p15.5 in non-small cell lung carcinomas reveals allelic deletion of one shared and one distinct region when compared to breast carcinomas.

@article{Tran1996HighdensityMA,
  title={High-density marker analysis of 11p15.5 in non-small cell lung carcinomas reveals allelic deletion of one shared and one distinct region when compared to breast carcinomas.},
  author={Y. Tran and I. Newsham},
  journal={Cancer research},
  year={1996},
  volume={56 13},
  pages={
          2916-21
        }
}
  • Y. Tran, I. Newsham
  • Published 1996
  • Biology, Medicine
  • Cancer research
  • The presence of a non-small cell lung carcinoma (NSCLC)-related gene or genes on chromosome band 11p15.5 is of particular interest, given the specific loss of heterozygosity (LOH) measured in this region for lung as well as many other pediatric and adult neoplasms. We have undertaken high-density polymorphic marker analysis in 30 matched normal and NSCLC tumor samples using 11 PCR-based polymorphic markers positioned approximately every 2-3 cM throughout 11p15.5. These studies have confirmed… CONTINUE READING
    Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers.
    95
    Lack of parental origin specificity of altered alleles at 11p15 in testicular germ cell tumors.
    4

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 29 REFERENCES
    Loss of heterozygosity for chromosome 11 in primary human breast tumors is associated with poor survival after metastasis.
    109
    Allelic losses in human chromosome II in lung cancers
    42