High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo.

@article{Bursill2010HighdensityLS,
  title={High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo.},
  author={Christina Anne Bursill and Maria Leticia Castro and Douglas T. Beattie and Shirley Nakhla and Emiel van der Vorst and Alison Kay Heather and Philip J.J. Barter and Kerry-Anne Rye},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2010},
  volume={30 9},
  pages={1773-8}
}
OBJECTIVE To investigate whether high-density lipoproteins (HDLs) suppress chemokine (CCL2, CCL5, and CX(3)CL1) and chemokine receptor (CCR2 and CX(3)CR1) expression, a mechanism for the atheroprotective properties of HDLs. METHODS AND RESULTS Apolipoprotein (apo) E(-/-) mice were fed a high-fat diet for 12 weeks. Before being euthanized, the mice received 5 consecutive daily injections of lipid-free apoA-I, 40 mg/kg, or saline (control). The injection of apoA-I reduced CCR2 and CX(3)CR1… CONTINUE READING
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