High density lipoproteins facilitate hepatitis C virus entry through the scavenger receptor class B type I.

@article{Voisset2005HighDL,
  title={High density lipoproteins facilitate hepatitis C virus entry through the scavenger receptor class B type I.},
  author={C{\'e}cile Voisset and Nathalie Callens and E. A. Blanchard and Anne Op de beeck and Jean Dubuisson and N Vu-dac},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 9},
  pages={7793-9}
}
The scavenger receptor class B type I (SR-BI) has recently been shown to interact with hepatitis C virus (HCV) envelope glycoprotein E2, suggesting that it might be involved at some step of HCV entry into host cells. However, due to the absence of a cell culture system to efficiently amplify HCV, it is not clear how SR-BI contributes to HCV entry. Here, we sought to determine how high density lipoproteins (HDLs), the natural ligand of SR-BI, affect HCV entry. By using the recently described… CONTINUE READING
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