High-density lipoproteins and ATP-binding cassette transporters as targets for cardiovascular drug therapy.

@article{Schmitz2005HighdensityLA,
  title={High-density lipoproteins and ATP-binding cassette transporters as targets for cardiovascular drug therapy.},
  author={Gerd Schmitz and Thomas Langmann},
  journal={Current opinion in investigational drugs},
  year={2005},
  volume={6 9},
  pages={907-19}
}
The recently identified lipid-regulated group of ATP-binding cassette (ABC) transporters acts in various cells and tissues that are important for total body lipid homeostasis. ABCA1 and ABCG1 are key regulators of high-density lipoprotein (HDL) metabolism, acting as protective factors against the development of atherosclerosis. Recent data regarding how these ABC transporters control cholesterol and phospholipid homeostasis have provided valuable insights into the mechanisms of mRNA and protein… CONTINUE READING