High-density lipoprotein suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide.

@article{Suzuki2010HighdensityLS,
  title={High-density lipoprotein suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide.},
  author={Masashi Suzuki and David K. Pritchard and Lev Becker and Andrew N Hoofnagle and Natsuko Tanimura and Theo K. Bammler and Richard P. Beyer and Roger Eugene Bumgarner and Tom{\'a}{\vs} Vaisar and Marcielle C de Beer and Frederick C. de Beer and Kensuke Miyake and John F. Oram and Jay W. Heinecke},
  journal={Circulation},
  year={2010},
  volume={122 19},
  pages={
          1919-27
        }
}
BACKGROUND High-density lipoprotein (HDL) protects the artery wall by removing cholesterol from lipid-laden macrophages. However, recent evidence suggests that HDL might also inhibit atherogenesis by combating inflammation. METHODS AND RESULTS To identify potential antiinflammatory mechanisms, we challenged macrophages with lipopolysaccharide, an inflammatory microbial ligand for Toll-like receptor 4. HDL inhibited the expression of 30 (277 of 911) of the genes normally induced by… CONTINUE READING

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