High density lipoprotein particle size restriction in apolipoprotein A-I(Milano) transgenic mice.

@article{Bielicki1997HighDL,
  title={High density lipoprotein particle size restriction in apolipoprotein A-I(Milano) transgenic mice.},
  author={John K. Bielicki and Trudy M. Forte and Mark R. McCall and L J Stoltzfus and Giulia Maria Chiesa and Cesare R. Sirtori and Guido Franceschini and Edward M. Rubin},
  journal={Journal of lipid research},
  year={1997},
  volume={38 11},
  pages={2314-21}
}
Human carriers of apolipoprotein A-I(Milano) (Arg173 --> Cys substitution in apolipoprotein A-I) are characterized by an HDL deficiency in which small, dense HDL accumulate in plasma. Because affected individuals are heterozygous for this mutation, the full impact of apolipoprotein A-I(Milano) (apoA-I(Milano)) on HDL-cholesterol metabolism is unknown. In this study, apoA-I(Milano) transgenic mice were used to evaluate the extent of apoA-I(Milano) dimerization and HDL particle size restriction… CONTINUE READING

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