High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice.

@article{Lehti2013HighdensityLM,
  title={High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice.},
  author={Maarit Lehti and Elizabeth Donelan and William A Abplanalp and Omar Al-Massadi and Kirk M Habegger and Jon Weber and Chandler Ress and Johannes Mansfeld and Sonal Somvanshi and Chitrang J Trivedi and Michaela Keuper and Teja Ograjsek and Cynthia Striese and Sebastian Cucuruz and Paul T Pfluger and Radhakrishna Krishna and Scott Michael Gordon and R. A. Gangani D. Silva and Serge Luquet and Julien Castel and Sarah E. Martinez and David A D'Alessio and W. Sean Davidson and Susanna M. Hofmann},
  journal={Circulation},
  year={2013},
  volume={128 22},
  pages={2364-71}
}
BACKGROUND Abnormal glucose metabolism is a central feature of disorders with increased rates of cardiovascular disease. Low levels of high-density lipoprotein (HDL) are a key predictor for cardiovascular disease. We used genetic mouse models with increased HDL levels (apolipoprotein A-I transgenic [apoA-I tg]) and reduced HDL levels (apoA-I-deficient [apoA-I ko]) to investigate whether HDL modulates mitochondrial bioenergetics in skeletal muscle. METHODS AND RESULTS ApoA-I ko mice exhibited… CONTINUE READING