High-density lipoprotein is a potential growth factor for adrenocortical cells.

@article{Murao2006HighdensityLI,
  title={High-density lipoprotein is a potential growth factor for adrenocortical cells.},
  author={Koji Murao and Hitomi Imachi and Wenming Cao and Xiao Yun Yu and Junhua Li and Kazuya Yoshida and Rania Abdel-Muneem Ahmed and Kensuke Matsumoto and Takamasa Nishiuchi and Norman C. W. Wong and Toshihiko Ishida},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={344 1},
  pages={226-32}
}
The entry of cholesterol contained within high-density lipoprotein (HDL) into adrenocortical cells is mediated by a human homologue of SR-BI, CD36, and LIMPII Analogous-1 (CLA-1) and thus augmenting their growth. To address the role of CLA-1, we created a mutant mCLA that lacked the C-terminal tail. HDL CE selective uptake by cells carrying the mCLA-1 receptor was fully active and equivalent to those transfected with full-length CLA-1 (fCLA-1). Expression of mCLA inhibited the proliferation of… CONTINUE READING