High-density lipoprotein facilitates in vivo delivery of α-tocopherol-conjugated short-interfering RNA to the brain.

Abstract

We originally reported the use of vitamin E (α-tocopherol) as an in vivo vector of short-interfering RNA (siRNA) to the liver. Here, we apply our strategy to the brain. By combining high-density lipoprotein (HDL) as a second carrier with α-tocopherol-conjugated siRNA (Toc-siRNA) in the brain, we achieved dramatic improvement of siRNA delivery to neurons… (More)
DOI: 10.1089/hum.2010.083

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@article{Uno2011HighdensityLF, title={High-density lipoprotein facilitates in vivo delivery of α-tocopherol-conjugated short-interfering RNA to the brain.}, author={Yoshitaka Uno and W. C. Piao and Kanjiro Miyata and Kazutaka Nishina and Hidehiro Mizusawa and Takanori Yokota}, journal={Human gene therapy}, year={2011}, volume={22 6}, pages={711-9} }