High density lipoprotein complexes as delivery vehicles for anticancer drugs.

@article{Lacko2002HighDL,
  title={High density lipoprotein complexes as delivery vehicles for anticancer drugs.},
  author={Andras G. Lacko and Maya P Nair and Sulabha Paranjape and Shemedia Johnso and Walter J Mcconathy},
  journal={Anticancer research},
  year={2002},
  volume={22 4},
  pages={2045-9}
}
MATERIALS AND METHODS Recombinant high density lipoprotein (rHDL) particles were prepared with defined composition (phosphatidylcholine, apolipoprotein A-1, cholesterol and cholesteryl esters) and a molecular weight of approximately 187,000 kdaltons. Three molecules of taxol per rHDL particle were incorporated into these rHDL complexes. RESULTS Cholesteryl ester and taxol (HDL core components,) were taken up efficiently by several cancer cell lines compared to transformed normal ovarian cells… CONTINUE READING
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