High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression.

@article{Feuerborn2017HighDL,
  title={High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression.},
  author={Renata Feuerborn and Susen Becker and Francesco Pot{\`i} and Petra Nagel and Martin F. Brodde and Harmut H-J Schmidt and Christina Lee Christoffersen and Uta Ceglarek and Ralph Burkhardt and J R Nofer},
  journal={Atherosclerosis},
  year={2017},
  volume={257},
  pages={29-37}
}
BACKGROUND AND AIMS Macrophage apoptosis is critically involved in atherosclerosis. We here examined the effect of anti-atherogenic high density lipoprotein (HDL) and its component sphingosine-1-phosphate (S1P) on apoptosis in RAW264.7 murine macrophages. METHODS Mitochondrial or endoplasmic reticulum-dependent apoptosis was induced by exposure of macrophages to etoposide or thapsigargin/fukoidan, respectively. RESULTS Cell death induced by these compounds was inhibited by S1P as inferred… CONTINUE READING

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