High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors.

@article{Ojalvo2009HighdensityGE,
  title={High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors.},
  author={Laureen S. Ojalvo and William Clyde King and Dianne Cox and Jeffrey W Pollard},
  journal={The American journal of pathology},
  year={2009},
  volume={174 3},
  pages={
          1048-64
        }
}
Clinical and experimental evidence indicates that tumor-associated macrophages (TAMs) promote malignant progression. In breast cancer, TAMs enhance tumor angiogenesis, tumor cell invasion, matrix remodeling, and immune suppression against the tumor. In this study, we examined late-stage mammary tumors from a transgenic mouse model of breast cancer. We used flow cytometry under conditions that minimized gene expression changes to isolate a rigorously defined TAM population previously shown to be… CONTINUE READING

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