High-density and very-low-density lipoprotein have opposing roles in regulating tumor-initiating cells and sensitivity to radiation in inflammatory breast cancer.

@article{Wolfe2015HighdensityAV,
  title={High-density and very-low-density lipoprotein have opposing roles in regulating tumor-initiating cells and sensitivity to radiation in inflammatory breast cancer.},
  author={Adam R Wolfe and Rachel L. Atkinson and Jay P Reddy and Bisrat G Debeb and Richard Larson and Li Li and Hiroko Masuda and Takae M. Brewer and Bradley J. Atkinson and Abeena Brewster and Naoto T Ueno and Wendy A Woodward},
  journal={International journal of radiation oncology, biology, physics},
  year={2015},
  volume={91 5},
  pages={
          1072-80
        }
}
PURPOSE We previously demonstrated that cholesterol-lowering agents regulate radiation sensitivity of inflammatory breast cancer (IBC) cell lines in vitro and are associated with less radiation resistance among IBC patients who undergo postmastectomy radiation. We hypothesized that decreasing IBC cellular cholesterol induced by treatment with lipoproteins would increase radiation sensitivity. Here, we examined the impact of specific transporters of cholesterol (ie lipoproteins) on the responses… CONTINUE READING
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