High-density Lipoproteins and Apolipoprotein A-I: Potential New Players in the Prevention and Treatment of Lung Disease

@inproceedings{Gordon2016HighdensityLA,
  title={High-density Lipoproteins and Apolipoprotein A-I: Potential New Players in the Prevention and Treatment of Lung Disease},
  author={Elizabeth M. Gordon and Debbie M. Figueroa and Amisha V. Barochia and Xianglan Yao and Stewart J Levine},
  booktitle={Front. Pharmacol.},
  year={2016}
}
Apolipoprotein A-I (apoA-I) and high-density lipoproteins (HDL) mediate reverse cholesterol transport out of cells. Furthermore, HDL has additional protective functions, which include anti-oxidative, anti-inflammatory, anti-apoptotic, and vasoprotective effects. In contrast, HDL can become dysfunctional with a reduction in both cholesterol efflux and anti-inflammatory properties in the setting of disease or the acute phase response. These paradigms are increasingly being recognized to be active… CONTINUE READING
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