High densities of benzodiazepine receptors in human cortical areas

@article{Braestrup1977HighDO,
  title={High densities of benzodiazepine receptors in human cortical areas},
  author={Claus Braestrup and R. Albrechtsen and Richard Felt Squires},
  journal={Nature},
  year={1977},
  volume={269},
  pages={702-704}
}
THE presence of brain-specific benzodiazepine receptors in membranes from rat brain is now established1–4. Highly significant correlations between the affinities of various benzodiazepines for the benzodiazepine receptor site in rat brain on the one hand and clinically predictive pharmacological activities in several species on the other, strongly suggest that the benzodiazepine receptor in vitro is related to a physiologically relevant receptor for benzodiazepines in vivo. We report here that… 
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388 Citations

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Benzodiazepines bind with high affinity to a specific benzodiazepine receptor, which occurs exclusively in the central nervous system, which has its highest density in cortical areas of the brain.
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The labelling of benzodiazepine receptors in vivo permits studies of receptor occupancy in various pharmacological and physiological conditions as well as autoradiographic localisation of the receptor in situ.
Recent studies on the brain benzodiazepine receptor
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  • 1984
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The light microscopic autoradiographic localisation of BZ receptors in mammalian central nervous system (CNS) and, to the authors' knowledge, the first receptor autorardiography in human brain tissue are reported for the first time.
Brain benzodiazepine receptor changes in the isolated aggressive mouse.
Heterogeneity of Benzodiazepine Receptors in the Central Nervous System Demonstrated with Kenazepine, an Alkylating Benzodiazepine
: Binding studies using the alkylating benzodiazepine kenazepine strongly suggest the existence of several populations of benzodiazepine receptors in the CNS. Kenazepine reacts noncompetitively and…
Benzodiazepine receptor sites in the human brain: Autoradiographic mapping
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