High densities of benzodiazepine receptors in human cortical areas

  title={High densities of benzodiazepine receptors in human cortical areas},
  author={Claus Braestrup and R. Albrechtsen and Richard Felt Squires},
THE presence of brain-specific benzodiazepine receptors in membranes from rat brain is now established1–4. Highly significant correlations between the affinities of various benzodiazepines for the benzodiazepine receptor site in rat brain on the one hand and clinically predictive pharmacological activities in several species on the other, strongly suggest that the benzodiazepine receptor in vitro is related to a physiologically relevant receptor for benzodiazepines in vivo. We report here that… 
The Benzodiazepine Receptor in Normal and Pathological Human Brain
Benzodiazepines bind with high affinity to a specific benzodiazepine receptor, which occurs exclusively in the central nervous system, which has its highest density in cortical areas of the brain.
Benzodiazepine receptor in brain
The evidence that the brain possesses specific receptors for benzodiazepines is summarized. Further we present a series of brain lesion experiments in rats showing that specific neuronal destructions
Labelling of benzodiazepine receptors in vivo
The labelling of benzodiazepine receptors in vivo permits studies of receptor occupancy in various pharmacological and physiological conditions as well as autoradiographic localisation of the receptor in situ.
Recent studies on the brain benzodiazepine receptor
  • J. Waddington
  • Biology, Psychology
    Irish journal of medical science
  • 1984
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Autoradiographic localisation of benzodiazepine receptors in the brains of humans and animals
The light microscopic autoradiographic localisation of BZ receptors in mammalian central nervous system (CNS) and, to the authors' knowledge, the first receptor autorardiography in human brain tissue are reported for the first time.
Brain benzodiazepine receptor changes in the isolated aggressive mouse.
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: Binding studies using the alkylating benzodiazepine kenazepine strongly suggest the existence of several populations of benzodiazepine receptors in the CNS. Kenazepine reacts noncompetitively and


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Experiments suggest that another important group of psychoactive drugs, the benzodiazepines, bind to specific receptors on the membranes of rat brain cells, and this suggests that there may be an unknown endogenous neurotransmitter which is the natural ligand for the Benzodiazepine receptor.
Neurotransmitter receptor binding: regional distribution in human brain
INVESTIGATIONS of neurotransmitter levels and enzyme activities in human postmortem brains have helped elucidate the pathophysiology of conditions such as Parkinson's disease (HORNYKIEWICZ, 1972) and
Dopamine receptors in human and calf brains, using [3H]apomorphine and an antipsychotic drug.
Since there was little desorption of [3H]apomorphine, the ligand permits extensive washing during routine assays for dopamine receptors, and facilitates biochemical purification of the receptor.
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3H( + )BM might be more suitable for GABA receptor binding studies than GABA itself, which in contrast to bicuculline, is chemically sufficiently stable.
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The development and application of a sensitive and specific radioimmunoassay for substance P, which is found to possess equipotent activity in multiple bioassays when compared to natural bovine substance P.