High cyclin E/low p27Kip1 expression is associated with poor prognosis in astrocytomas

@article{Tamiya2001HighCE,
  title={High cyclin E/low p27Kip1 expression is associated with poor prognosis in astrocytomas},
  author={Takashi Tamiya and Shinichiro Mizumatsu and Yasuhiro Ono and Tomoyasu Abe and Kengo Matsumoto and Tomohisa Furuta and Takashi Ohmoto},
  journal={Acta Neuropathologica},
  year={2001},
  volume={101},
  pages={334-340}
}
Cyclin E and p27Kip1 are co-regulators of the G1-to S-phase transition and closely related to tumor behavior. The purpose of this study was to examine expression of cyclin E and p27Kip1 in astrocytomas and to evaluate the relationships between expression of these cell-cycle regulators and prognosis of patients with astrocytoma. Tissue samples from 130… CONTINUE READING