High-curvature domains of the ER are important for the organization of ER exit sites in Saccharomyces cerevisiae.

@article{Okamoto2012HighcurvatureDO,
  title={High-curvature domains of the ER are important for the organization of ER exit sites in Saccharomyces cerevisiae.},
  author={Michiyo Okamoto and Kazuo Kurokawa and Kumi Matsuura-Tokita and Chieko Saito and Ryogo Hirata and Akihiko Nakano},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 14},
  pages={3412-20}
}
Protein export from the endoplasmic reticulum (ER) to the Golgi apparatus occurs at specialized regions known as the ER exit sites (ERES). In Saccharomyces cerevisiae, ERES appear as numerous scattered puncta throughout the ER. We examined ERES within the peripheral ER, finding that the proteins comprising the ERES localize on high-curvature ER domains where curvature-stabilizing protein Rtn1 is present. Δrtn1 Δrtn2 Δyop1 cells have fewer high-curvature ER domains, but ERES accumulate at the… CONTINUE READING
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