High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers.

@article{Nishida2007HighCA,
  title={High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers.},
  author={Naoshi Nishida and Takeshi Nagasaka and Kazuhiro Kashiwagi and Clement Richard Boland and Ajay Goel},
  journal={Cancer biology & therapy},
  year={2007},
  volume={6 4},
  pages={525-33}
}
Chromosomal instability (CIN) is a common but not universal feature of colorectal cancer (CRC); however, the molecular basis for CIN is controversial and poorly understood. There are many plausible mechanisms proposed for CIN, including disruption of G1/S and G2/M checkpoint regulation, and alterations in the spindle checkpoint genes. However, mutations in individual growth regulatory genes are not commonly observed in CRC. Therefore, a more comprehensive analysis of the genes involved in each… CONTINUE READING

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There are many plausible mechanisms proposed for CIN , including disruption of G1/S and G2/M checkpoint regulation , and alterations in the spindle checkpoint genes .
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