High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

@inproceedings{Azorsa2008HighcontentSS,
  title={High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation},
  author={David O Azorsa and Rilee H Robeson and Danielle Frost and Bessie Meec hoovet and Gillian R Brautigam and Chad A Dickey and Christian Beaudry and Gargi D. Basu and David Holz and Joseph A Hernandez and Kristen M Bisanz and Leslie Gwinn and Andrew Grover and Joseph Rogers and Eric M. Reiman and M. Hutton and Dietrich A. Stephan and Spyro Mousses and Travis L. Dunckley},
  booktitle={BMC Genomics},
  year={2008}
}
Neurofibrillary tangles (NFT), a cardinal neuropathological feature of Alzheimer's disease (AD) that is highly correlated with synaptic loss and dementia severity, appear to be partly attributable to increased phosphorylation of the microtubule stabilizing protein tau at certain AD-related residues. Identifying the kinases involved in the pathologic phosphorylation of tau may provide targets at which to aim new AD-modifying treatments. We report results from a screen of 572 kinases in the human… CONTINUE READING