High-content screening for compounds that affect mtDNA-encoded protein levels in eukaryotic cells.

@article{Nadanaciva2010HighcontentSF,
  title={High-content screening for compounds that affect mtDNA-encoded protein levels in eukaryotic cells.},
  author={Sashi Nadanaciva and Keith S Dillman and David F Gebhard and Alka Shrikhande and Yvonne Will},
  journal={Journal of biomolecular screening},
  year={2010},
  volume={15 8},
  pages={937-48}
}
Compounds that interfere with the synthesis of either mitochondrial DNA or mtDNA-encoded proteins reduce the levels of 13 proteins essential for oxidative phosphorylation, leading to a decrease in mitochondrial adenosine triphosphate (ATP) production. Toxicity caused by these compounds is seldom identified in 24- to 72-h cytotoxicity assays due to the low… CONTINUE READING
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