High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.

Abstract

An increasing body of evidence points to mitochondrial dysfunction as a contributor to the molecular pathogenesis of neurodegenerative diseases such as Parkinson's disease. Recent studies of the Parkinson's disease associated genes PINK1 (ref. 2) and parkin (PARK2, ref. 3) indicate that they may act in a quality control pathway preventing the accumulation… (More)
DOI: 10.1038/nature12748

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Cite this paper

@article{Hasson2013HighcontentGR, title={High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.}, author={Samuel A Hasson and Lesley A. Kane and Koji Yamano and Chiu-Hui Huang and Danielle A. Sliter and Eugen C. Buehler and Chunxin Wang and Sabrina Mahalia Heman-Ackah and Tara Hessa and Rajarshi Guha and Scott E. Martin and Richard J Youle}, journal={Nature}, year={2013}, volume={504 7479}, pages={291-5} }