High-content analysis for drug delivery and nanoparticle applications.

  title={High-content analysis for drug delivery and nanoparticle applications.},
  author={David J Brayden and Sally-Ann Cryan and Kenneth A. Dawson and Peter James O'Brien and Jeremy C Simpson},
  journal={Drug discovery today},
  volume={20 8},
High-content analysis (HCA) provides quantitative multiparametric cellular fluorescence data. From its origins in discovery toxicology, it is now addressing fundamental questions in drug delivery. Nanoparticles (NPs), polymers, and intestinal permeation enhancers are being harnessed in drug delivery systems to modulate plasma membrane properties and the intracellular environment. Identifying comparative mechanistic cytotoxicity on sublethal events is crucial to expedite the development of such… CONTINUE READING