High-content analysis/screening for predictive toxicology: application to hepatotoxicity and genotoxicity.

@article{Persson2014HighcontentAF,
  title={High-content analysis/screening for predictive toxicology: application to hepatotoxicity and genotoxicity.},
  author={Mikael Persson and Anni F L{\o}ye and M{\'e}lanie Jacquet and Natacha S Mow and Annemette V Thougaard and Tomas Mow and Jorrit J. Hornberg},
  journal={Basic & clinical pharmacology & toxicology},
  year={2014},
  volume={115 1},
  pages={
          18-23
        }
}
High-content imaging/analysis has emerged as a powerful tool for predictive toxicology as it can be used for identifying and mitigating potential safety risks during drug discovery. By careful selection of end-points, some cellular assays can show better predictivity than routine animal toxicity testing for certain adverse events. Here, we present the perhaps most utilized high-content screening assays for predictive toxicology in the pharmaceutical industry. Multi-parametric imaging of cell… CONTINUE READING

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