High-conductance calcium-activated potassium channels in rat brain: pharmacology, distribution, and subunit composition.

@article{Wanner1999HighconductanceCP,
  title={High-conductance calcium-activated potassium channels in rat brain: pharmacology, distribution, and subunit composition.},
  author={Siegmund G. Wanner and Robert O. Koch and Alexandra Koschak and Maria Trieb and M. L. Garcia and Gregory J. Kaczorowski and H G Knaus},
  journal={Biochemistry},
  year={1999},
  volume={38 17},
  pages={5392-400}
}
In rat brain, high-conductance Ca2+-activated K+ (BK) channels are targeted to axons and nerve terminals [Knaus, H. G., et al. (1996) J. Neurosci. 16, 955-963], but absolute levels of their regional expression and subunit composition have not yet been fully established. To investigate these issues, an IbTX analogue ([125I]IbTX-D19Y/Y36F) was employed that selectively binds to neuronal BK channels with high affinity (Kd = 21 pM). Cross-linking experiments with [125I]IbTX-D19Y/Y36F in the… CONTINUE READING
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