High concentrations of stavudine impair fatty acid oxidation without depleting mitochondrial DNA in cultured rat hepatocytes.

@article{Igoudjil2008HighCO,
  title={High concentrations of stavudine impair fatty acid oxidation without depleting mitochondrial DNA in cultured rat hepatocytes.},
  author={Anissa Igoudjil and J. -P. Massart and Karima Begriche and V{\'e}ronique Descatoire and M T Robin and Bernard Fromenty},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2008},
  volume={22 4},
  pages={887-98}
}
The antiretroviral nucleoside reverse-transcriptase inhibitor (NRTI) stavudine (d4T) can induce mild to severe liver injuries such as steatosis (i.e. triglyceride accumulation), steatohepatitis and liver failure. NRTI-induced toxicity has been ascribed to the inhibition of mitochondrial DNA (mtDNA) replication causing mtDNA depletion and respiratory chain… CONTINUE READING