High concentrations of soluble P-selectin are associated with risk of venous thromboembolism and the P-selectin Thr715 variant.

@article{Ay2007HighCO,
  title={High concentrations of soluble P-selectin are associated with risk of venous thromboembolism and the P-selectin Thr715 variant.},
  author={Cihan Ay and Lea V. Jungbauer and Thomas R Sailer and Theres Tengler and Silvia Koder and Alexandra Kaider and Simon Panzer and Peter Quehenberger and Christoph C. Zielinski and Christine Mannhalter},
  journal={Clinical chemistry},
  year={2007},
  volume={53 7},
  pages={
          1235-43
        }
}
BACKGROUND The cell adhesion molecule P-selectin has an important role in the pathophysiology of thrombosis. The effect on venous thromboembolism (VTE) of increased circulating concentrations of soluble P-selectin (sP-selectin) and their association with the P-selectin variant Thr715Pro is still uncertain. METHODS This study was a case-control study of 116 patients with confirmed recurrent VTE and at least 1 event of unprovoked deep venous thrombosis or pulmonary embolism, and 129 age- and… CONTINUE READING

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