High concentrations of retinoids induce differentiation and late apoptosis in pancreatic cancer cells in vitro.

@article{ElMetwally2005HighCO,
  title={High concentrations of retinoids induce differentiation and late apoptosis in pancreatic cancer cells in vitro.},
  author={Tarek Hassan El-Metwally and Mahmoud Rezk Abdelwahed Hussein and Parviz Moradi Pour and Charles A. Kuszynski and Thomas Edward Adrian},
  journal={Cancer biology & therapy},
  year={2005},
  volume={4 5},
  pages={
          602-11
        }
}
BACKGROUND Our previous investigations showed that retinoids, at specific concentrations, can inhibit cell proliferation. In this investigation, we hypothesize that high concentrations of retinoids can induce phenotypic changes (differentiation) and late apoptosis in pancreatic cancer cells in vitro. MATERIALS AND METHODS To test our hypothesis, retinoid-induced differentiation was assessed: (1) phenotypically by light and electron microscopy and (2) biochemically by measuring carbonic… CONTINUE READING
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