High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates.

@article{Daar1990HighCO,
  title={High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates.},
  author={Eric S Daar and Xiao-Ling Li and Tarsem L. Moudgil and David D. Ho},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 17},
  pages={6574-8}
}
There is substantial evidence supporting the CD4 molecule as the principal cellular receptor for the human immunodeficiency virus type 1 (HIV-1). A number of truncated recombinant soluble CD4 (sCD4) molecules have been produced and shown to easily neutralize infection of laboratory strains of HIV-1 in vitro, and clinical trials using these sCD4 preparations have begun in patients with AIDS. Infectious HIV-1 titers in the plasma and peripheral blood mononuclear cells of five patients receiving… CONTINUE READING

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